Of particular interest is their involvement in metabolic pathways or pathways linked to events potentially related to excess body weight, e.g., the regulation of lipolysis in adipocytes, the insulin signaling pathway, insulin resistance, type II diabetes mellitus, the GnRH signaling pathway, the estrogen signaling pathway, the thyroid hormone signaling pathway, the TNF signaling pathway, or the IL-17 signaling pathway. This evidence concerns the gene INS and type 2 diabetes mellitus.