Between the SV vs. OB and SV vs. OW comparisons, several OMIM genes associated with dilated cardiomyopathy (VCL, ABCC9, ACTN2, PSEN1, MYH7, DSP, TAZ, FKTN, EYA4, TNNC1, TNNT2, TMPO, LDB3, TNNI3, MYBPC3, TPM1, PSEN2, TTN, ACTC1, LMNA, SGCD, TCAP, DES, SCN5A, PLN, and DMD, all of which were downregulated) and with obesity (SIM1, POMC, LEPR, PPARG, FTO, NTRK2, AKR1C2, PPARGC1B, GHRL, SDC3, ADRB2, LEP, PCSK1, UCP3, UCP2, ADRB3, and ENPP1, all of which were upregulated) were identified. The gene discussed is PSEN2; the disease is obesity due to melanocortin 4 receptor deficiency.