TYR and oculocutaneous albinism type 1: Li et al. (2018) used BE3 and SCNT to develop one pig model for the ablepharon macrostamia syndrome (AMS) in humans, which is caused by a point mutation in the TWIST2 gene, and another pig model for the oculocutaneous albinism type 1 (OCA1), caused by mutation of the TYR gene [279].