Furthermore, in the absence of multivariable analyses, it remains unproven whether the prognostic information provided by the described CMR variables is independent from or adds to that of previously identified clinical prognosticators in pediatric PAH, such as WHO-FC, tricuspid annular plane systolic excursion (TAPSE) and NT-proBNP. This evidence concerns the gene NPPB and pulmonary arterial hypertension.