VEGFA and ventricular septal defect: The first study analyzed the rs699947 (c.-2578C > A) variant of the VEGF gene and found a significant statistical difference in the frequencies of the A and C alleles in children with isolated VSD and controls, suggesting that the presence of the A allele can increase the rate for heart development issues (allelic odds ratio for A versus C was 2.03, with a confidence interval (CI) of 1.41–2.92 and a p-value of 0.0001) [59].