The study of Vannay et al. [99] on a Hungarian population of 86 preterm newborns with a birth weight under 1500 g (VLBW) and ROP showed that the VEGF -460TT/+405CC haplotype was more dominant in preterm with treatment than in the preterm without treatment (13 of 86 versus 1 of 115; p < 0.001), and the correlation remained significant (p < 0.01) even after the correction to risk factors of ROP (gestational age, gender, oxygen therapy). The gene discussed is VEGFA; the disease is retinopathy of prematurity.