INSL3 and cryptorchidism: Investigating whether prenatal exposure to diethylstilbestrol, a synthetic estrogen that can conduct to cryptorchidism in humans and rodents, could interfere with testicular INSL3 mRNA expression, Emmen et al. [18] pointed out that this therapy resulted in a three-fold decrease in the INSL3 mRNA expression level and inhibits the development of the gubernaculum during the transabdominal phase of testis descent.