GALNS and mucopolysaccharidosis type 4B: There are two different forms of MPS IV, each one caused by a single enzymatic defect: N-acetyl-galactosamine-6-sulfatase (GALNS; EC 3.1.6.4) deficiency underlies MPS IVA (OMIM #253000) while β-galactosidase (EC 3.2.1.23) defects cause MPS IVB (OMIM #253010).