RRM2 and pancreatic ductal adenocarcinoma: Multiple Yes-associated protein/TEA domain family member (YAP/TEAD)-regulated genes, including ZWILCH among other genes (AJUBA, ANLN, AREG, ARHGAP29, AURKA, BUB1, CCND1, CDK6, CXCL5, ED N2, DKK1, FOSL1, FOXM1, HBEGF, IGFBP2, JAG1, NOTCH2, RHAMM, RRM2, SERP1), have been linked to poor survival outcomes in individuals with pancreatic ductal adenocarcinoma [17].