Another study, which focused on the identification of 164 sorafenib resistance-related DEGs in hepatocellular carcinoma has revealed ZWILCH as important DEGs (DYNLL2, H2AFJ, SHANK2, ZWILCH, CDC14A, IFT20, MTA3, SERPINA1, and TCF4) involved in regulating multiple biological processes [16]. This evidence concerns the gene TCF4 and hepatocellular carcinoma.