ATM and neoplasm: Furthermore, functional exploration of the five signature genes in the Wikipathways database affirms their roles in tumor-associated pathways, including retinoblastoma tumor regulation, DNA damage response, DNA repair, Ataxia telangiectasia Mutated (ATM) signaling pathway, miRNA regulation of DNA damage response, 5′ adenosine monophosphate-activated protein kinase (AMPK) signaling, cell cycle regulation, and DNA damage response (FDR ≤ 0.02) (Table S3).