Intriguingly, we found that these genes were significantly enriched in the pathways associated with cell cycle, PLK1 and Aurora B kinase signaling, DNA replication, FOXM1 transcription factor (TF) network, G2/M checkpoints, and p73 transcription factor network, which are highly dysregulated biological processes in many types of cancer (Figure 3b). The gene discussed is PLK1; the disease is cancer.