AKT1 and atherosclerosis: Down-regulated hub DEGs are involved in KEGG pathways such as hypoxia-inducible factor-1 (HIF-1) signaling pathway (hsa04066), inflammatory mediator regulation of TRP channels (hsa04750), platelet activation (hsa04611), apoptosis (hsa04210), fluid shear stress and atherosclerosis (hsa05418), ATP-binding cassette (ABC) transporters (hsa02010), PI3K-Akt signaling pathway (hsa04151), and mitogen-activated protein kinase (MAPK) signaling pathway (hsa04010) (Figure 3B).