The disorders strongly linked with the three collagens, COL11A2, COL13A1, and COL15A1, also exhibit a strong correlation with other genes: hyperthyroidism thyrotoxicosis, with MUC22; malignant neoplasm of the thyroid gland, with SLIT2; malabsorption and coeliac disease, with SFTA2; and heart failure, with GPC6 (Supplementary Table S7). The gene discussed is GPC6; the disease is heart failure.