FN1 and Ehlers-Danlos syndrome: Age-related changes in the ECM, such as collagen degradation, elastase upregulation, and fibronectin upregulation, may prime the cellular environment for increased risk of disease development and accelerated aging pathology, and the crossover of certain attributes of diseases such as EDS and Marfan syndrome with the ECM aging phenotype may provide insights into how aged ECMs and certain disease states may communicate [54].