Furthermore, experimental studies in mice have found that endothelial cell-derived ANGPTL2 accelerates vascular inflammation most likely by activating integrin α5β1/Rac1/NF-ΚB proinflammatory pathway in endothelial cells and increasing macrophage infiltration, leading to endothelial dysfunction and progression of the atherosclerotic process [26]. Here, RAC1 is linked to endothelial dysfunction.