Using Hpb in the PAC IL-10−/− model, our laboratory initially demonstrated that colonization with helminths inhibits colitis and reverses intestinal pathology while suppressing the Th1-associated proinflammatory cytokines, interferon-γ (IFNγ) and interleukin 12 (IL12), and upregulating the Th2 cytokine IL13 and the expression regulatory T cell (Treg)-specific transcription factor Foxp3 in small bowel lamina propria mononuclear cells (LPMC) [10]. This evidence concerns the gene FOXP3 and colitis.