Specifically, predicted mRNA targets of DE miRNAs were involved in significant canonical pathways, including osteoarthritis pathway [−log(p-value) = 50.04], hepatic fibrosis [−log(p-value) = 39.46], role of osteoblasts and chondrocytes in rheumatoid arthritis [−log(p-value) = 36.67], IL-17 signalling [−log(p-value) = 19.86], HIF1α signalling [−log(p-value) = 18.89] and others (Figure 2A). The gene discussed is HIF1A; the disease is rheumatoid arthritis.