The lncRNA NBR2 inhibits Beclin 1-dependent autophagy and suppresses autophagy-induced cell proliferation in HCC [262], while Forkhead box O3 (FOXO3), a member of the FOXO subfamily of transcription factors, upregulates autophagy, acting on ULK1, Beclin-1 and LC3 [263]. Here, FOXO3 is linked to hepatocellular carcinoma.