These findings were corroborated in curative resection specimens from HCC patients where the reduced expression of Beclin-1 was negatively correlated with survival only in the Bcl-xL+ patients, indicating that an increased expression of the anti-apoptotic gene Bcl-xL was associated with decreased expression of Beclin-1 and a poor prognosis [334]. This evidence concerns the gene BCL2L1 and hepatocellular carcinoma.