TNFRSF25 and systemic lupus erythematosus: Taking into account that the HLA-DR region (particularly the DR3 allele) is the dominant lupus susceptibility locus and the importance of T cells in SLE development, Zhao et al. showed multiple intramolecular DR3 restricted T cell epitopes in the Sm D protein, from which they generated a non-homologous, bacterial epitope mimicry library.