Increased metal concentration in the brain may contribute to various AD-associated pathological processes including Aβ-aggregation [30,31], hyperphosphorylation of tau protein [32,33], neuroinflammation [34], oxidative stress [35], blood–brain barrier (BBB) impairment [36], apoptosis and necrosis of neurons [37,38], and autophagy [39] (Figure 1). The gene discussed is MAPT; the disease is Alzheimer disease.