FOS and diabetes mellitus: Based on the higher activity of spinal dorsal horn neurons in diabetic animals [66,68,69] and the vortioxetine-induced decrease in the levels of c-Fos, a marker of neuronal activation, it can be suggested that vortioxetine inhibits the hyperexcitability of spinal cord dorsal horn neurons in diabetic rats and thus reduces diabetes-induced neuropathic pain.