Although accumulation of AGEs in individuals is a normal phenomenon, excessive accumulation of AGEs results in various deleterious effects on cell metabolism, neuronal apoptosis, and induction of the tau-protein kinases that are involved in the formation of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT) in the brains of AD cases [1,24,60]. This evidence concerns the gene MAPT and Alzheimer disease.