HMGB1 and systemic lupus erythematosus: Pisetsky D et al. [144] previously described the exposure of HMGB1 on apoptotic microparticles, while Hartl J and colleagues [143] demonstrated that DNASE1L3 controls this phenomenon through the digestion of HMGB1–DNA complexes, overall suggesting a new potential therapeutic target in the monogenic forms of SLE [143].