B. thetaiotaomicron has been reported to induce NF-κB-relaxed aspartate-auxotrophic-PPARγ complexes in colon cancer cell line (Caco-2) cells in vitro and to downregulate NF-κB-induced inflammatory genes such as TNFα [39]. The gene discussed is NFKB1; the disease is malignant colon neoplasm.