Concerning the other clinical variables exhibiting a significant association with OS, higher age, Gleason score, ECOG-PS, tALP, and PSA, as well as the presence of lymphadenopathies at the time of enrollment, resulted independently associated with an increased risk of death, while previous primary treatment (radical prostatectomy/radiotherapy) and higher baseline Hb values significantly associated with better outcomes. The gene discussed is KLK3; the disease is Lymphadenopathy.