Coupled with E-cadherin, membranous downregulation and increased nuclear TGF-β expression were also observed in dog PCa [39,113,114,115], Additionally, Wnt signaling is likely to be a key event in the progression of PCa in this species; therefore, dog PCa may be a good model for phases of human PCa that are reliant on this aberrant pathway (i.e., CRPC and mCRPC). The gene discussed is TGFB1; the disease is posterior cortical atrophy.