The most frequently reported NAFLD-related genetic variants associated with NAFLD have been identified in the genes of PNPLA3, a member of the transmembrane superfamily 6 2 (TM6SF2), glucokinase regulatory protein (GCKR), as well as membrane-bound protein 7 containing the O-acyltransferase domain (MBOAT7), GCKR, and 17-β hydroxysteroid dehydrogenase 13 (HSD17B13). This evidence concerns the gene GCKR and metabolic dysfunction-associated steatotic liver disease.