Several experts have defined MAFLD as the relationship of fatty liver disease with obesity, type 2 diabetes mellitus (T2DM) or at least two factors connected with the symptoms of metabolic dysfunction including elevated waist circumference (WC), increased serum C-reactive protein, prediabetes (pre-DM), increased blood pressure, reduced level of high density lipoprotein (HDL-CH), and increased level of triglycerides (TG). Here, C4B is linked to type 2 diabetes mellitus.