However, the association between LOXL1 and liver cancer or pathophysiology has not been well known; however, about a 30-fold increase in the mRNA expression level of LOXL1 has been reported in a CCl4-induced liver cirrhosis mouse model [56], but the detailed mechanism requires further investigation, and its relation with liver cancer is not well known. The gene discussed is LOXL1; the disease is cirrhosis of liver.