It was also shown that the suppression of NRF2 might increase the expression of other tumor suppressors, such as miR-27b-3p, which diminishes aggressive features related to the proliferation, migration, invasion, and epithelial-to-mesenchymal transition of esophageal squamous cell carcinoma (ESCC) [41]. Here, NFE2L2 is linked to esophageal squamous cell carcinoma.