Numerous studies have reported that TMZ-resistant GBM cells typically have high NRF2 expression levels, and that its silencing and/or pharmacological inhibition induce apoptosis in tumor cells, thus restoring chemosensitivity; this demonstrates the importance of NRF2 regulation in apoptotic cell death in TMZ-resistant GBM cells [84,85]. This evidence concerns the gene NFE2L2 and neoplasm.