Granier et al. has already demonstrated that RCC patients with tumor-infiltrating CD8 cells co-expressing PD-1 and TIM-3 experienced a more aggressive phenotype, as shown by a high Fuhrman grade, a larger tumor size, and more advanced TNM and UISS (UCLA Integrated Staging System) scores [82]. This evidence concerns the gene HAVCR2 and renal cell carcinoma.