Activated KRAS protein interacts with more than 80 downstream effector proteins and signaling pathways such as mitogen-activated protein kinase (MAPK)/MAPK kinase (MEK), phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR), and the rapidly accelerated fibrosarcoma (RAF)/MEK/extracellular signal-regulated kinase (ERK) pathways [92]. The gene discussed is MAP2K7; the disease is fibrosarcoma.