GALC and Krabbe disease: Krabbe disease is caused by the mutations in the GALC (in human)/Galc (in mouse) gene, which encodes an enzyme known as GALCERase (EC 3.2.1.46) critical for catabolism of GalCer, which is present in myelin, kidney, epithelial cells of the small intestine and the colon and responsible for the maintenance of proper structure and stability of myelin and differentiation of oligodendrocytes [57,184].