In a model of human Gaucher disease using conduritol B epoxide (CBE)-induced GCase-targeted Mφs stimulated with GC-ICs, there was an increase in the production of pro-inflammatory cytokines, including IFNγ, TNFα, IL1β, IL6, IL12, IL17, IL21, and IL23 [5,7,76]. Here, TNF is linked to Gaucher disease.