MAPK8 and GM2 gangliosidosis: In particular, the mTOR, LAT, PI3K, AKT, JNK, RIPK3, ERK, MAP3K1, and p38MAP signaling has been implicated in the regulation of lysosomal biogenesis, autophagy, and complement activation, which are key cellular processes involved in the tissue damage in GM2 gangliosidosis, mucopolysaccharidosis, Niemann–Pick type C, Gaucher, and Fabry diseases [36,157,158,338,339,340,341,342,343,344,345,346,347,348,349].