These effects have been observed in several Gba1 prone models, such as Gbaflox/flox; Nestin-Cre mice, K14-lnl/lnl mice, 4L; C*, C57BL/6J-Gbatm1Nsb, as well as Conduritol B epoxide-induced chemical model of neuronopathic Gaucher disease [78,84,85,86,87,88,89,90,91,92,93,94]. The gene discussed is GBA1; the disease is Gaucher disease.