This is supported here by the elevated level of growth factors (e.g., MCSF, GCSF, and GMCSF), chemoattractants (C3a, C5a, CCL2, CCL3, CCL4, CCL5, CCL10, CCL11, CCL12, CXCL1, CXCL9, CXCL10, CXCL11, and CXCL13), and the increased presence of MOs, granulocytes, MOs-differentiated Mφs and DCs, T cells, NK cells, NKT cells, antibodies producing plasma B cells in circulation and the peripheral organs of the different lysosomal storage diseases [6,7,11,36,76,112,113,157,158,165,176,186,194,203,204,222,233,234,235,236,237,238,239,240,241,242,243,244]. The gene discussed is C5AR1; the disease is lysosomal storage disease.