GLA and Fabry disease: Fabry disease occurs due to GLA (in human)/Gla (in mouse) defect and the resultant deficiency of the lysosomal enzyme α Gal A (E.C. 3.2.1.22) and the excess accumulation of glycosphingolipids, mainly Gb3 and lyso-Gb3 in the affected cells and body fluids [8,9,10,11,12,13,14,15,16,105].