In particular, the mTOR, LAT, PI3K, AKT, JNK, RIPK3, ERK, MAP3K1, and p38MAP signaling has been implicated in the regulation of lysosomal biogenesis, autophagy, and complement activation, which are key cellular processes involved in the tissue damage in GM2 gangliosidosis, mucopolysaccharidosis, Niemann–Pick type C, Gaucher, and Fabry diseases [36,157,158,338,339,340,341,342,343,344,345,346,347,348,349]. The gene discussed is AKT1; the disease is Fabry disease.