TNF and GM1 gangliosidosis: The neuroprogenator cells (NPSCs) from patients with GM1 gangliosidosis have shown higher levels of TNF α, IL1β, and IL6, Additionally, GLB1 gene defects and the resultant excess accumulation of GM1 have been linked to the microglial cells activation, excess generation of pro-inflammatory cytokines, and chemokines that lead to the neurodegeneration, motor function defects, and the hind limb paralysis in GM1 gangliosidosis [121,122,124].