It is not surprising that, in cancer, NF-κB controls cell proliferation, epithelial-to-mesenchymal transition (EMT), survival, invasion, metastasis, and angiogenesis, in addition to the development of cancer stem cells, cellular metabolism, genetic and epigenetic changes, and resistance to therapy in the tumor microenvironment (TME). The gene discussed is NFKB1; the disease is neoplasm.