According to the immunohistochemical analysis in the present study, caspase-3 expression in DEN-treated mice significantly decreased (p < 0.05) and was significantly augmented by Streptomyces sp.(A16) extract in a dose-dependent manner, demonstrating the capacity of Streptomyces sp.(A16) to induce apoptosis of cancers liver cells (Figure 7). Here, CASP3 is linked to cancer.