DNMT3A and idiopathic pulmonary fibrosis: TGF-β1 is a potential modifier of the DNA methylome; therefore, stimulation with the TGF-β1 modified DNA methylation of normal and IPF fibroblasts are characterized by the significantly decreased expression of THY-1 and the up-regulation of DNMT1, DNMT3a, and DNMT3b [140].