A total of 3 out of 20 PID patients (PID1, PID7 with previous COVID-19 plus two doses of vaccine and PID11 with indeterminate IFN-γ titers after two doses of vaccine) had positive PCR for SARS-CoV-2 during the sixth wave of the coronavirus in Spain, all of them related to mild symptoms. The gene discussed is IFNG; the disease is COVID-19.