The potential mechanism of miR-503 in regulating cardiovascular disease involves the following targets: fibroblast growth factor (FGF)2, fibroblast growth factor receptor (FGFR)1, vascular endothelial growth factor (VEGF)A, TGF-β, CTGF, nuclear factor erythroid 2–related factor 2 (Nrf2), and phosphatidylinositol 3-Kinase (PI3K)/protein kinase B (Akt) in the pathological processes of cardiovascular diseases. This evidence concerns the gene VEGFA and cardiovascular disorder.