In the Bio-SHiFT (The Role of Biomarkers and Echocardiography in Prediction of Prognosis of Chronic Heart Failure Patients) study of 263 patients with chronic HF, repeatedly measured miR-22-3p contained important prognostic information and remained statistically significant after adjustment for temporal patterns of NT-proBNP, Troponin T, and CRP [42]. Here, CRP is linked to congestive heart failure.