A knockdown of syntenin-1 using cell lines derived from lung cancer (NCI-H1299 and NCI-H226) shows that the axis Ras/Syntenin-1 stimulated the release of extracellular vesicles charged with onco-miRNA to promote the tumor growth, cell migration, metastasis, and angiogenesis. Here, SDCBP is linked to neoplasm.