Additionally, it regulates the differentiation and angiogenesis in head and neck squamous cell carcinoma (HNSCC) by interacting with SPRR1B and VEGFR1 [100], and the phosphorylation of syntenin-1 mediated by AURKA promotes the progression of the HNSCC [101] and allows the modulation of the stemness and chemoresistance [102]. This evidence concerns the gene SPRR1B and head and neck squamous cell carcinoma.