VEGFA and hepatocellular carcinoma: Moreover, a separate metanalysis of five trials (REACH, REACH-2, METIV-HCC, CELESTIAL, and JET-HCC for a total of 2083 patients) did not show an impact of etiology on outcome of TKIs/anti-VEGF, as no differences in efficacy were found between the viral and non-viral HCCs (p = 0.88) [60].