The remarkable efficacy of immunotherapy in HCC was recently confirmed by the positive results of the HIMALAYA trial, in which the anti PD-L1 antibody durvalumab plus the anti-cytotoxic T lymphocyte antigen 4 (CTLA4) tremelimumab combination provided a statistically significant survival benefit compared to sorafenib in the first-line [9]. Here, CD274 is linked to hepatocellular carcinoma.