CD8A and neoplasm: In this “immune” class, two subtypes were identified according to distinct TME characteristics: (1) an “Immune Active” subclass, with high tumor infiltrating lymphocytes (TILs), increased CD8+ T cell and M1 macrophages infiltration, activated IFN signaling, and overexpression of adaptative immune response related genes; tumors pertaining to this subclass demonstrate favorable prognosis and better response to ICIs; and (2) an “Immune Exhausted” subclass, characterized by an activated stroma, increased infiltration of M2 macrophages and exhausted T cells, and high levels of TGFβ signaling [33].