Briefly, Clavaguera and coworkers showed that injecting tau aggregates extracted from mice overexpressing mutated tau (P301S) into mice overexpressing human wild-type tau was sufficient to induce tau pathology in anatomically connected brain regions, and reproduced the morphology of the lesions seen in human disease in rodent brains by injecting human brain homogenates of different tauopathies [12,47]. Here, MAPT is linked to tauopathy.