In their work, Van Schoor et al. [420] observed increases in the NLRP3 inflammasome, GSDMD-N fragments, and IL-18 in the motor cortex and spinal cord microglia of human ALS patients, which suggested that an activated NLRP3 inflammasome had triggered the cells’ pyroptosis. This evidence concerns the gene IL18 and amyotrophic lateral sclerosis.