APP and Alzheimer disease: Then again, Wang et al. [368] showed that LPS stimulation or lentivirus-mediated TREML2 overexpression remarkably upregulated NLRP3 inflammasome activation; IL-1β, IL-6, and TNF-α secretion; and proinflammatory M1-type polarization in microglia of APP/PS1 AD-model mice.