NLRP3 and Alzheimer disease: Saresella et al. [371] reported the occurrence of a significantly upregulated expression of mRNAs encoding for NLRP1; NLRP3; ASC/PYCARD; caspase-1, -5, and -8; pro-IL-1β; and pro-IL-18 in monocytes isolated from MCI or late-stage AD patients.