NLRP3 and myeloid sarcoma: Moreover, Vidmar et al. [397] highlighted as pathogenetically important for MS patients the increased burden of rare variants in (i) NLRP1 and NLRP3 genes; (ii) genes partaking in inflammasome downregulation via autophagy and IFN-β; and (iii) genes involved in responses to type-1 IFNs (e.g., PTPRC, TYK2) and to DNA virus infections (e.g., DHX58, POLR3A, IFIH1).