Johann et al. [127] showed that an activated NLRP3 inflammasome concurred with elevated levels of caspase-1, IL-1β, and IL-18, particularly in the spinal cord astrocytes of the SOD1G93A ALS-model mice and in the serum and spinal cord tissue of sporadic ALS patients—altogether findings confirming NLRP3 inflammasome’s involvement in ALS. The gene discussed is CASP1; the disease is amyotrophic lateral sclerosis.