In their work, Van Schoor et al. [420] observed increases in the NLRP3 inflammasome, GSDMD-N fragments, and IL-18 in the motor cortex and spinal cord microglia of human ALS patients, which suggested that an activated NLRP3 inflammasome had triggered the cells’ pyroptosis. The gene discussed is NLRP3; the disease is amyotrophic lateral sclerosis.