Moreover, Chen et al. [429] showed that NLRP3 inhibitor MCC950 given to R6/2 HD-model mice suppressed IL-1β and ROS overproduction, mitigating neuroinflammation, motor dysfunction, and neuronal pyroptosis, while upregulating PSD-95 and NeuN proteins, and lengthening animals’ lifespans. The gene discussed is NLRP3; the disease is Huntington disease.