Immunohistochemical studies conducted on samples of temporal cerebral cortex of AD brains showed that the increased expression of NLRP3 inflammasome’s constituents, including pro-caspase-1, and of IL-1β and IL-18, co-localized with glia maturation factor (GMF), APOE-ε4, sequestosome 1 (SQSTM1)/p62, LC3-positive autophagic vesicles, and LAMP1, a lysosomal marker. This evidence concerns the gene CASP1 and Alzheimer disease.