-reduced A4 by 19% (TRLIK066: TRPCB [A4]: 0.81; 90% CI: 0.68–0.99; p = 0.089)-reduced DHEAS by 24% (TRLIK066: TRPCB [DHEAS]: 0.76; 90% CI: 0.65–0.89; p = 0.008).-increased SHBG by 15% (TRLIK066:TRPCB [SHBG]: 1·15; 90% CI: 0.97–1.36; p = 0.173),-Hyperinsulinemia reduced by 70% by licogliflozin (highest insulin concentration [MAXI]; TRLIK066:TRPCB [MAXI]: 0·26; 90% CI:0.20–0.34; p < 0.001 and area under the curve insulin [AUCI]; TRLIK066:TRPCB [AUCI]: 0.32; 90% CI: 0.25–0.41; p < 0.001). The gene discussed is INS; the disease is Hyperinsulinemia.