CASP3 and breast carcinoma: Figure S1A shows a dot-plot of annexin V-FITC fluorescence versus PI fluorescence, which reveals that SFN-treated cells exhibited a non-significant increase in the percentage of apoptotic cells when compared with untreated (control) cells (Figure S1A). Additionally, there were no significant changes in the percentage of SFN-treated breast cancer cells undergoing necrosis, apoptosis, or caspase-3 activity (Figure S1B).