CRHR1 and hydrops fetalis: (5) Comparing m changes of specific proteins in HF and after LVAD placement, a decrease in the ratio of phosphorylated ERK42 / ERK42 and phosphorylated ERK44/ERK44 (extracellular signal-regulated kinase) was observed, p 38 MAPK phosphorylation remained unchanged, AKT phosphorylation did not change statistically significantly, phosphorylation of the cell growth regulator mTOR (mechanistic target of rapamycin) remained elevated, stress marker CRF1 (corticotropin-releasing factor receptor) increased while CRF2 (which is involved in Akt and ERK activation) decreased.