Thus, we could hypothesize that the reduced expression of lnc-EGFR observed here might result in decreased Tregs cell numbers and/or dysregulated Treg cells with impaired immunosuppressive function, as evidenced by the observed low levels of FOXP3 and TGF-β1, which subsequently could participate in the pathogenesis of RRMS, particularly in the immune-mediated events during relapses. Here, TGFB1 is linked to relapsing-remitting multiple sclerosis.