These findings comply with the neuroinflammatory roles of SNHG1 and lincRNA-Cox2 in other neurodegenerative diseases and imply that the impact of both lncRNAs on RRMS pathogenesis and disease activity might be mediated, at least partially, via targeting NLRP3 inflammasome activation. The gene discussed is PTGS2; the disease is neurodegenerative disease.