Pearson’s correlation analyses revealed that the expression of lnc-EGFR was negatively correlated with age, number of relapses in the last 2 years, ARR, EDSS score, SNHG1, lincRNA-Cox2, NLRP3, ASC, caspase-1, and IL-1β in RRMS patients. The gene discussed is NLRP3; the disease is relapsing-remitting multiple sclerosis.