The results of multivariate Cox regression analysis demonstrated that log10PIVKA-II (HR: 1.347, 95% CI: 1.121–1.780), GGT (HR: 1.002, 95% CI: 1.001–1.003), and ALB (HR: 0.932, 95% CI: 0.888–0.979) were independent variables for the prognosis of HCC (Table 4). This evidence concerns the gene ALB and hepatocellular carcinoma.