In the multivariate logistic regression analysis, increasing age (OR: 1.08, 95% CI 1.050–1.116; p < 0.001), male gender (OR: 2.662, 95% CI 1.159–6.117; p = 0.021), elevated AFP (OR: 8.291, 95% CI 4.366–15.743; p < 0.001), increased PIVKA-II (OR: 12.231, 95% CI 5.853–25.559; p < 0.001), decreased TP (OR: 0.912, 95% CI 0.871–0.954; p < 0.001), and prolonged PT (OR: 0.839, 95% CI 0.752–0.935; p = 0.002) were independent predictors of HCC. The gene discussed is AFP; the disease is hepatocellular carcinoma.