In homozygous knockout mice, Ma and Adelstein, when studying the expression of non-muscle myosin (variant IIB), it was found that a point mutation (R709C) of the gene Myh10 is associated with cardiac abnormalities and midline defects (cleft palate, ectopia cordis, omphalocele, diaphragmatic hernia) because of a dominant negative effect [15]. The gene discussed is MYH10; the disease is diaphragmatic hernia.