Genetic factors are associated with the development of NAFLD in lean individuals, including patatin-like phospholipase domain-containing 3 (PNPLA3, rs738409 C > G) and transmembrane 6 superfamily member 2 (TM6SF2, rs58542926 C > T) [19,20]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.