Recently, d’Alessandro et al. found potential evidence of the CD4 highCD25 highCXCR5 high cell’s role in sarcoidosis progression because patients showed higher percentages of Tfr cells in the peripheral blood vs. in the controls, and percentages of alveolar Tfr cells were positively correlated with Scadding stages [81]. The gene discussed is TFRC; the disease is sarcoidosis.