Transcriptome analysis revealed that in Huh7.5 hepatoma cells, the expression of polyamine biosynthesis genes (SRM, SMS, and AMD) was increased, while in hepatocyte-like HepaRG cells, the expression of the SAT1 gene involved in the degradation of spermine and spermidine was increased (Figure 4a,b). The gene discussed is SAT1; the disease is hepatocellular carcinoma.