The comparison of proliferative hepatoma Huh7.5 cells with non-proliferative differentiated non-tumor HepaRG cells revealed significantly higher levels of the mRNAs of polyamine biosynthesis genes (AMD, ODC, SRM, SMS) and lower levels of SAT1, which encodes the main catabolic enzyme with non-constitutive expression. This evidence concerns the gene ODC1 and neoplasm.