For example, mutations in Cx43 are associated with oculodentodigital dysplasia [16,17], a pleiotropic disorder that includes variable neurological manifestations such as seizures, cognitive deficits, and white matter abnormalities on imaging, [18,19,20,21], and mutations in Cx32 cause the most common form of X-linked Charcot Marie Tooth disease (CMTX1). Here, GJA1 is linked to oculodentodigital dysplasia.