PDGFRB and dementia: Overall, our data are consistent with the idea that (i) soluble PDGFRβ isoforms are present in the normal murine brain, likely generated by pre-mRNA alternative splicing, and (ii) corresponding sPdgfrβ transcripts, which were similarly detected in human cells, are sensitive to aging and hypoxia–two factors that can fuel cerebrovascular dysfunction, neurodegeneration, and in turn, memory loss and dementia.