ADAM10 and Mental deterioration: For instance, in the setting of amyloid-beta exposure or severe hypoxia (1% O2), human pericytes are proposed to shed a soluble isoform of PDGFRβ in the size range of ~160 kDa [5], suggested to be an indicator of A Disintegrin And Metalloproteinase domain-containing protein 10 (ADAM10) activity, BBB breakdown, and cognitive decline [32].