Similarly, we found that either inhibition of non-selective channels with boldine or preventing the expression of Cx HCs in myofibers deficient in Cx43 and Cx45 expression did not present muscle atrophy because of diabetes, suggesting that the inactivity or absence of Cx43 and Cx45 HCs would be sufficient to prevent the cascade of events leading to negative skeletal muscle outcomes. The gene discussed is GJA1; the disease is diabetes mellitus.