By performing feature selection algorithms, MIFS, we screened a subset of 20 protein signatures (including MYH11, HER3_pY1289, CD20, STATHMIN, SMAD1, CHK1, P27_pT157, JAB1, PCADHERIN, IGF1R_pY1135Y1136, BCLXL, PREX1, PR, MIG6, ERCC1, CHK1_pS345, AR, CYCLIND1, HER3, and ADAR1) for better classification among the ESCA, STAD, and CRC tumour samples. This evidence concerns the gene PREX1 and colorectal carcinoma.